CKM Glu83Gly Is Associated With Blunted Creatine Kinase Variation, but Not With Myalgia [Original Articles]

Conclusions— This study highlights that a genetic factor known to be associated with constitutive CK levels is also associated with CK variability and inducibility. This is discussed in the context of evidence to suggest that the variant has an impact on inducibility of CK by trauma through a previously reported case of a homozygous carrier. However, the lack of association between the variant and myalgia suggests that it cannot reliably be used as a biomarker for muscle symptoms.

http://circgenetics.ahajournals.org/cgi/content/short/10/4/e001737?rss=1

Source: Circulation: Cardiovascular Genetics - August 8, 2017 Category: Cardiology Authors: Siddiqui, M. K., Veluchamy, A., Maroteau, C., Tavendale, R., Carr, F., Pearson, E., Colhoun, H., Morris, A. D., George, J., Doney, A., Pirmohamed, M., Alfirevic, A., Wadelius, M., Maitland van der Zee, A. H., Ridker, P. M., Chasman, D. I., Palmer, C. N. A Tags: Biomarkers, Cardiovascular Disease, Genetic, Association Studies Original Articles Source Type: research