Multiple Gene Variants in Hypertrophic Cardiomyopathy in the Era of Next-Generation Sequencing [Original Articles]

Conclusions—
No proband had multiple LP/P variants in contrast to previous reports. However, multiple rare variants regardless of classification were seen in 4% and contributed to earlier disease onset and cardiac events. Our findings support a cumulative variant hypothesis in hypertrophic cardiomyopathy.

Source: Circulation: Cardiovascular Genetics - August 8, 2017 Category: Cardiology Authors: Burns, C., Bagnall, R. D., Lam, L., Semsarian, C., Ingles, J. Tags: Genetics, Quality and Outcomes Original Articles Source Type: research