Relationship of PIK3CA mutation and pathway activity with anti-proliferative response to aromatase inhibition

Conclusions: PIK3CA mutations are associated with classical markers of good prognosis and signatures of PI3K pathway activity. The presence of a PIK3CA mutation does not preclude a response to neoadjuvant anastrozole treatment.

http://breast-cancer-research.com/content/16/3/R68

Source: Breast Cancer Research - June 30, 2014 Category: Cancer & Oncology Authors: Elena López-KnowlesCorrinne SegalQiong GaoIsaac Garcia-MurillasNicholas TurnerIan SmithLesley-Ann MartinMitch Dowsett Source Type: research