TNFRp55 deficiency promotes the development of ectopic endometriotic-like lesions in mice

In conclusion, the deficiency of TNFRp55 promoted the establishment and development of endometriosis through an increase in the lesion size and high levels of estradiol which correlate with an increase in the MMP-2 activity. This is evidence of the possible association of the deregulation of the TNFRp55 expression and the survival of the endometriotic tissue in ectopic sites.

Source: Journal of Endocrinology - August 4, 2017 Category: Endocrinology Authors: Vallcaneras, S., Ghersa, F., Baston, J., Delsouc, M. B., Meresman, G., Casais, M. Tags: Research Source Type: research