Multiplex analysis of plasma cytokines/chemokines showing different immune responses in active TB patients, latent TB infection and healthy participants

Interferon gamma release assays (IGRAs) have been widely used to diagnose Mycobacterium tuberculosis (MTB) infection. However, IGRAs cannot discriminate between active TB patients and latent TB infection (LTBI), and the sensitivity of IGRAs for MTB infection is suboptimal. Here, we analyzed cytokines/chemokines in MTB antigen-stimulated and -unstimulated plasma samples to identify host biomarkers that are associated with active TB and MTB infection. Active TB patients, subjects with LTBI and healthy participants were recruited.

Source: Tuberculosis - August 3, 2017 Category: Respiratory Medicine Authors: Xiangyang Yao, Yongliang Liu, Yang Liu, Wei Liu, Zhizhong Ye, Chao Zheng, Shengxiang Ge Tags: Diagnostics Source Type: research