CTL immunogenicity of Rv3615c antigen and diagnostic performances of an ESAT-6/CFP-10/Rv3615c antigen cocktail for Mycobacterium tuberculosis infection

T cell immune responses have played pivotal roles in host immune protection against Mycobacterium tuberculosis (MTB) infection. MTB specific antigen, Rv3615c (EspC), was identified to be as immunodominant as the well-known ESAT-6 and CFP-10, and has brought promising expectations to a more sensitive T-cell based diagnosis and vaccine development. However, limited knowledge about the immunogenicity and diagnostic values of this antigen has restricted its application in clinical practice. Herein, the Rv3615c antigen was identified as a robust CTL immunoantigen with broadly cross-human leucocyte antigen allele recognized peptides which may contribute to the broad recognition of Rv3615c antigen among the population.

Source: Tuberculosis - August 2, 2017 Category: Respiratory Medicine Authors: Shuguang Tan, Nan Lin, Mingxiang Huang, Qing Wang, Yunhong Tan, Bingxi Li, Ning Zhang, Tianling Guo, Yingbin Cui, Xinchao Chen, Dongping Wang, Jue Wang, Haixia Xiao, William J. Liu, Jinghua Yan, Catherine W.-H. Zhang, Cui Hua Liu, Kanglin Wan, George F. G Tags: Immunological Aspects Source Type: research