PCSK9 Loss-of-Function Variants, Low-Density Lipoprotein Cholesterol, and Risk of Coronary Heart Disease and Stroke: Data From 9 Studies of Blacks and Whites [Original Articles]

Conclusions—
PCSK9 LOF variants were associated with lower LDL-C and coronary heart disease incidence. PCSK9 LOF variants were not associated with stroke risk.

Source: Circulation: Cardiovascular Genetics - August 2, 2017 Category: Cardiology Authors: Kent, S. T., Rosenson, R. S., Avery, C. L., Chen, Y.-D. I., Correa, A., Cummings, S. R., Cupples, L. A., Cushman, M., Evans, D. S., Gudnason, V., Harris, T. B., Howard, G., Irvin, M. R., Judd, S. E., Jukema, J. W., Lange, L., Levitan, E. B., Li, X., Liu, Tags: Lipids and Cholesterol, Genetic, Association Studies, Myocardial Infarction, Meta Analysis, Cerebrovascular Disease/Stroke Original Articles Source Type: research