Development of diabetes does not alter behavioral and molecular circadian rhythms in a transgenic rat model of type 2 diabetes mellitus

We report that circadian activity, light-induced entrainment, molecular clockwork, as well as melatonin secretion are preserved in the HIP rat model of T2DM. These results suggest that despite the well-characterized ability of glucose to modulate circadian clock gene expression acutely in vitro, SCN clock function and key behavioral and physiological outputs appear to be preserved under chronic diabetic conditions characteristic of nonobese T2DM.

Source: AJP: Endocrinology and Metabolism - August 2, 2017 Category: Endocrinology Authors: Qian, J., Thomas, A. P., Schroeder, A. M., Rakshit, K., Colwell, C. S., Matveyenko, A. V. Tags: Research Article Source Type: research