Urine RAS components in mice and people with type 1 diabetes and chronic kidney disease

In conclusion, in mice with streptozotocin-induced diabetes and in humans with DKD, urine concentrations and enzymatic activities of several RAS components are concordantly increased, consistent with enhanced RAS activity and greater angiotensin II formation. ACEI use was associated with a specific reduction in urine ACE activity, not ACE protein concentration, suggesting that it may be a marker of exposure to this widely-used therapy.

Source: AJP: Renal Physiology - August 2, 2017 Category: Urology & Nephrology Authors: Wysocki, J., Goodling, A., Burgaya, M., Whitlock, K., Ruzinski, J., Batlle, D., Afkarian, M. Tags: RESEARCH ARTICLE Source Type: research