Protein phosphatase 2C is responsible for VP-induced dephosphorylation of AQP2 serine 261

In conclusion, PP2C activity is required for S261 AQP2 dephosphorylation upon VP stimulation, which occurs independently of S256 phosphorylation. Understanding the pathways involved in modulating PP2C will help elucidate the role of S261 in cellular events involving AQP2.

Source: AJP: Renal Physiology - August 2, 2017 Category: Urology & Nephrology Authors: Cheung, P. W., Ueberdiek, L., Day, J., Bouley, R., Brown, D. Tags: RESEARCH ARTICLE Source Type: research