Effect of sodium nitrite on renal function and sodium and water excretion and brachial and central blood pressure in healthy subjects: a dose-response study

In conclusion, intravenous NaNO2 induced a dose-dependent reduction of brachial and central BP. The hemodynamic effect was not mediated by the renin-angiotensin-aldosterone system. NaNO2 infusion resulted in a vasopressin-independent decrease in CH2O and urine output but no change in urinary sodium excretion or GFR. The lack of increase in cGMP accompanying the increase in NO2– suggests a direct effect of nitrite or nitrate on the renal tubules and vascular bed with little or no systemic conversion to NO.

Source: AJP: Renal Physiology - August 2, 2017 Category: Urology & Nephrology Authors: Rosenbaek, J. B., Al Therwani, S., Jensen, J. M., Mose, F. H., Wandall-Frostholm, C., Pedersen, E. B., Bech, J. N. Tags: RESEARCH ARTICLE Source Type: research