Hypoxia-inducible factor-1{alpha} activation improves renal oxygenation and mitochondrial function in early chronic kidney disease

In conclusion, we report significant impairment of renal oxygenation and mitochondrial function at the early stages of CKD and demonstrate the beneficial role of HIF-1α activation on renal function and metabolism.

Source: AJP: Renal Physiology - August 1, 2017 Category: Urology & Nephrology Authors: Thomas, J. L., Pham, H., Li, Y., Hall, E., Perkins, G. A., Ali, S. S., Patel, H. H., Singh, P. Tags: RESEARCH ARTICLE Source Type: research