EETs promote hypoxic pulmonary vasoconstriction via constrictor prostanoids

In conclusion, an EET-dependent alteration in PG metabolism that favors the action of vasoconstrictor PGH2 and TXA2 potentiates HPV and hypoxia-induced elevation of RVSP in sEH-deficient mice.

Source: AJP: Lung Cellular and Molecular Physiology - August 1, 2017 Category: Respiratory Medicine Authors: Kandhi, S., Zhang, B., Froogh, G., Qin, J., Alruwaili, N., Le, Y., Yang, Y.-M., Hwang, S. H., Hammock, B. D., Wolin, M. S., Huang, A., Sun, D. Tags: RESEARCH ARTICLE Source Type: research