Decreased phosphatase PTEN amplifies PI3K signaling and enhances proinflammatory cytokine release in COPD

In conclusion, oxidative stress reduces PTEN protein levels, which may result in increased PI3K signaling and amplification of inflammation in COPD.

Source: AJP: Lung Cellular and Molecular Physiology - August 1, 2017 Category: Respiratory Medicine Authors: Yanagisawa, S., Baker, J. R., Vuppusetty, C., Fenwick, P., Donnelly, L. E., Ito, K., Barnes, P. J. Tags: RESEARCH ARTICLE Source Type: research