Menin and PRMT5 suppress GLP1 receptor transcript and PKA-mediated phosphorylation of FOXO1 and CREB

In conclusion, our results suggest that menin and PRMT5 suppress GLP1R transcript levels and PKA-mediated phosphorylation of FOXO1 and CREB, and a menin inhibitor may reverse this suppression to induce β-cell proliferation.

Source: AJP: Endocrinology and Metabolism - August 1, 2017 Category: Endocrinology Authors: Muhammad, A. B., Xing, B., Liu, C., Naji, A., Ma, X., Simmons, R. A., Hua, X. Tags: Research Article Source Type: research