Role of thiosulfate in hydrogen sulfide-dependent redox signaling in endothelial cells

This report provides new evidence that different levels of exogenous thiosulfate dynamically change discrete sulfide biochemical metabolite bioavailability in endothelial cells under normoxia or hypoxia, acting in a slow manner to modulate sulfide metabolites. Moreover, our findings also reveal that thiosulfate surprisingly inhibits VEGF-dependent endothelial cell proliferation associated with a reduction in cystathionine--lyase protein levels.

Source: AJP: Heart and Circulatory Physiology - August 1, 2017 Category: Cardiology Authors: Leskova, A., Pardue, S., Glawe, J. D., Kevil, C. G., Shen, X. Tags: RESEARCH ARTICLE Source Type: research