Estradiol activates chloride channels via estrogen receptor-{alpha} in the cell membranes of osteoblasts

In conclusion, our findings show that Cl– channels can be activated by estrogen via ERα on the cell membrane and suggest that the ClC-3 Cl– channel may be one of the targets of estrogen in the regulation of osteoblast activity.

Source: AJP: Cell Physiology - August 1, 2017 Category: Cytology Authors: Deng, Z., Peng, S., Zheng, Y., Yang, X., Zhang, H., Tan, Q., Liang, X., Gao, H., Li, Y., Huang, Y., Zhu, L., Jacob, T. J. C., Chen, L., Wang, L. Tags: RESEARCH ARTICLE Source Type: research