Cancer: mRNA-encoded bispecific antibodies eliminate tumours

Nature Reviews Drug Discovery 16, 530 (2017). doi:10.1038/nrd.2017.145 Author: Sarah Crunkhorn The development of therapeutic bispecific T cell-engaging antibodies, which recruit cytotoxic T cells to tumour cells, has been hampered by manufacturing challenges as well as their short serum half-life. To circumvent these issues, Stadler et al. generated 1-methylpseudouridine-containing mRNAs encoding bispecific antibodies directed against
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: Research Highlight Source Type: research