Cancer: mRNA-encoded bispecific antibodies eliminate tumours
Nature Reviews Drug Discovery 16, 530 (2017).
doi:10.1038/nrd.2017.145
Author: Sarah Crunkhorn
The development of therapeutic bispecific T cell-engaging antibodies, which recruit cytotoxic T cells to tumour cells, has been hampered by manufacturing challenges as well as their short serum half-life. To circumvent these issues, Stadler et al. generated 1-methylpseudouridine-containing mRNAs encoding bispecific antibodies directed against
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Sarah Crunkhorn Tags: Research Highlight Source Type: research