Novel characterisation of mast cell phenotypes from peripheral blood mononuclear cells in chronic fatigue syndrome/myalgic encephalomyelitis patients

Conclusions: This preliminary study investigates mast cell phenotypes from PBMCs in healthy controls. We report  significant increase of naïve MCs in moderate and severe CFS/ME patients compared with healthy controls. Moreover, a significant increase in CD40 ligand and MHC-II receptors on differentiated mast cells in severe CFS/ME patients. Peripheral MCs may be present in CFS/ME pathology however, further investigation to determine their role is required.Key words: Chronic Fatigue Syndrome; Mast Cells; Receptor for advanced glycation end products; RAGE; Ligand High Mobility Group Box 1 protein (HMGB1); Myalgic Encephalomyelitis
Source: Asian Pacific Journal of Allergy and Immunology - Category: Allergy & Immunology Source Type: research