A key HDAC6 dependency of ARID1A-mutated ovarian cancer

Nature Cell Biology 19, 889 (2017). doi:10.1038/ncb3588 Author: Lucia Altucci Mutations in AT rich interactive domain 1A (ARID1A) are common in ovarian cancers. A study now shows that HDAC6 activity is required for survival of ovarian cancer cells bearing ARID1A mutations. HDAC6 inhibition selectively promotes apoptosis of ARID1A-inactivated cells, supporting the use of HDAC6 inhibition in the treatment of clear cell ovarian cancer.
Source: Nature Cell Biology - Category: Cytology Authors: Tags: News and Views Source Type: research