CTCF fences make good neighbours

Nature Cell Biology 19, 883 (2017).
doi:10.1038/ncb3584

Authors: Ivan Krivega & Ann Dean
CCCTC-binding factor (CTCF) sites are enriched at the boundaries of topologically associated domains (TADs), but their function within TADs is unclear. Removal of sub-TAD CTCF sites adjacent to the α-globin enhancers is now shown to result in inappropriate activation of neighbouring genes. Intra-TAD enhancer insulation might be broadly important for tissue specificity of enhancers.

Source: Nature Cell Biology - July 28, 2017 Category: Cytology Authors: Ivan Krivega Ann Dean Tags: News and Views Source Type: research