Dexmedetomidine pharmacokinetic –pharmacodynamic modelling in healthy volunteers: 1. Influence of arousal on bispectral index and sedation

Conclusions. The new pharmacokinetic –pharmacodynamic models might be used for effect-site rather than plasma concentration target-controlled infusion for dexmedetomidine in clinical practice, thereby allowing tighter control over the desired level of sedation.Clinical trial registration. NCT01879865.
Source: British Journal of Anaesthesia - Category: Anesthesiology Source Type: research