Monogenic immune disorders and severe atopic disease

Nature Genetics 49, 1162 (2017). doi:10.1038/ng.3925 Authors: Catherine M Biggs, Henry Y Lu & Stuart E Turvey Severe allergic disease is common, and few monogenic causes of atopy have been described. A new study that convincingly links severe atopic dermatitis to heterozygous CARD11 mutations with dominant-interfering activity serves as a timely reminder that clinicians should consider the possibility of an underlying monogenic immune disorder when caring for patients suffering from severe allergic disease.
Source: Nature Genetics - Category: Genetics & Stem Cells Authors: Tags: News and Views Source Type: research