Serine protease inhibitor Kazal type 1 (SPINK1) downregulates E ‐cadherin and induces EMT of hepatoma cells to promote hepatocellular carcinoma metastasis via the MEK/ERK signaling pathway

CONCLUSIONSPINK1 may be an oncogene that induces EMT via the MEK/ERK pathway and is a potential target for HCC therapy.

Source: Journal of Digestive Diseases - July 27, 2017 Category: Gastroenterology Authors: Hai Yan Ying, Chao Jie Gong, Yi Feng, Da Dao Jing, Lun Gen Lu Tags: Original Article Source Type: research