The Arl3 and Arl1 GTPases co ‐operate with Cog8 to regulate selective autophagy via Atg9 trafficking

In this study, we show that Arl3‐Arl1 small GTPase cascade co‐operates with the subunit of conserved oligomeric Golgi (COG) complex to control Cvt pathway but not non‐selective autophagy. The yeast strains with dysfunction of Arl3‐Arl1 cascade and COG complex accumulate Atg9 at the late Golgi in nutrient‐rich condition, thereby causing the defect of Cvt pathway. Thus, 2 Golgi‐endosomal traffic components co‐ordinately regulate the Cvt pathway by regulating Atg9 trafficking at the Golgi.

Source: Traffic - July 25, 2017 Category: Research Authors: I ‐Hao Wang, Yi‐Jie Chen, Jia‐Wei Hsu, Fang‐Jen S. Lee Tags: ORIGINAL ARTICLE Source Type: research