Post-transplant lymphoproliferative disorder after solid organ transplant in children
The post-transplant lymphoproliferative disorders (PTLD) are a diverse group of potentially life threatening conditions affecting organ transplant recipients. PTLD arises in the setting of an attenuated host immunologic system which is manipulated to allow a foreign graft but then fails to provide adequate immune surveillance of transformed malignant or pre-malignant lymphocytes. The diversity of biological behavior and clinical presentation makes for a challenging clinical situation for those involved in the care of children with PTLD occurring after solid organ transplantation.
Source: Seminars in Pediatric Surgery - Category: Pediatrics Authors: Michael J. Absalon, Ruby A. Khoury, Christine L. Phillips Source Type: research
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