Epigenetics: Tumour suppressive HIF2 α

Nature Reviews Cancer 17, 453 (2017). doi:10.1038/nrc.2017.64 Author: Anna Dart Westerlund et al. found that combining the DNA demethylating drug 5-aza-deoxycytidine with the differentiation-promoting therapy retinoic acid inhibited tumour growth and prolonged survival in mouse xenograft models of high-risk neuroblastoma. This treatment resulted in high hypoxia-inducible factor 2α (HIF2α) levels but not HIF1α, and
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Research Highlight Source Type: research