Therapeutic use of transferrin to modulate anemia and conditions of iron toxicity

As the main iron transporter, transferrin delivers iron to target tissues like the bone marrow for erythropoiesis. Also, by binding free iron, transferrin prevents formation of reactive oxygen species. Transferrin deficiency due to congenital hypotransferrinemia is characterized by anemia as well as oxidative stress related to toxic free iron. Transferrin supplementation may be beneficial in two ways. First, transferrin can correct anemia by modulating the amount of iron that is available for erythropoiesis.

Source: Blood Reviews - July 24, 2017 Category: Hematology Authors: M. Boshuizen, K. van der Ploeg, L. von Bonsdorff, B.J. Biemond, S.S. Zeerleder, R. van Bruggen, N.P. Juffermans Tags: Review Source Type: research