Effects of Lysine deficiency and Lys ‐Lys dipeptide on cellular apoptosis and amino acids metabolism

ConclusionsAltogether, these studies suggest that Lys deficiency impairs AA metabolism and causes apoptosis. Lys‐Lys dipeptide serves as a Lys source and alleviates Lys deficiency induced cellular imbalance.

Lysine is a common limiting amino acid and there is a potential risk of lysine deficiency existing in developing countries, which may cause various physical problems, such as immune suppression, lower growth performance, cell arrest, and metabolic imbalance. The results show that lysine deficiency impairs amino acid metabolism and causes apoptosis in IPEC‐J2 cells and mice. Lys‐Lys dipeptide serves as a lysine source and alleviates lysine deficiency induced cellular imbalance and apoptosis.

Source: Nahrung / Food - July 20, 2017 Category: Nutrition Authors: Jie Yin, Yuying Li, Hui Han, Jie Zheng, Lijian Wang, Wenkai Ren, Shuai Chen, Fei Wu, Rejun Fang, Xingguo Huang, Chunyong Li, Bie Tan, Xia Xiong, Yuzhe Zhang, Gang Liu, Jiming Yao, Tiejun Li, Yulong Yin Tags: Research Article Source Type: research