Effects of atipamezole on the analgesic activity of butorphanol in rats

The aim of this study was to evaluate the effect of atipamezole on the analgesic efficacy of butorphanol in rats. Forty adult male Wistar rats were used with the heart rate, respiratory rate, and plantar withdrawal latency being measured prior and following injection of butorphanol (B); atipamezole (A); butorphanol followed by atipamezole (BA); saline solution (S).Heart and respiratory rates in Group A was consistently higher than all other groups and in Group BA these physiologic paramaters were higher than that in Group B.
Source: Journal of Exotic Pet Medicine - Category: Veterinary Research Authors: Source Type: research