Neurodegenerative disorders: Amyloid clearance

Nature Reviews Neuroscience 18, 455 (2017). doi:10.1038/nrn.2017.97 Author: Sian Lewis Microglia play a part in protein clearance and synaptic pruning. This latter process is re-activated in Alzheimer disease (AD) and promoted by amyloid-β (Aβ). A screen of 18 AD-associated genes revealed that loss of the DNA–RNA binding protein TDP43 led to a considerable increase in
Source: Nature Reviews Neuroscience - Category: Neuroscience Authors: Tags: Research Highlight Source Type: research