Relationship Between Serum Inflammatory Marker Levels and the Dynamic Changes in Coronary Plaque Characteristics After Statin Therapy [Coronary Artery Disease]

Conclusions— With 12-month rosuvastatin therapy, a greater hsCRP reduction (not low-density lipoprotein-cholesterol) was associated with a greater decrease in %necrotic core volume and the absence of VH-TCFA, indicating a link between the anti-inflammatory action of statin and plaque stabilization by reducing NC and reinforcing fibrous cap. Clinical Trial Registration— URL: https://www.clinicaltrials.gov. Unique identifier: NCT00997880.

http://circimaging.ahajournals.org/cgi/content/short/10/7/e005934?rss=1

Source: Circulation: Cardiovascular Imaging - July 5, 2017 Category: Radiology Authors: Kwon, O., Kang, S.-J., Kang, S. H., Lee, P. H., Yun, S.-C., Ahn, J.-M., Park, D.-W., Lee, S.-W., Kim, Y.-H., Lee, C. W., Han, K. H., Park, S.-W., Park, S.-J. Tags: Imaging, Treatment Coronary Artery Disease Source Type: research