Fatigability, Exercise Intolerance, and Abnormal Skeletal Muscle Energetics in Heart Failure [Original Articles]

Conclusions
Symptomatic fatigue during plantar flexion exercise occurs at a common energetic limit in all subjects. HFrEF and HFpEF patients with EI and increased fatigability manifest early, rapid exercise-induced declines in SM high-energy phosphates and reduced oxidative capacity compared with healthy and low-fatigability HF patients, suggesting that SM metabolism is a potentially important target for future HF treatment strategies.

Source: Circulation: Heart Failure - July 13, 2017 Category: Cardiology Authors: Weiss, K., Schar, M., Panjrath, G. S., Zhang, Y., Sharma, K., Bottomley, P. A., Golozar, A., Steinberg, A., Gerstenblith, G., Russell, S. D., Weiss, R. G. Tags: Metabolism, Heart Failure, Exercise Testing, Magnetic Resonance Imaging (MRI) Original Articles Source Type: research