The effects of physical exercise on nonmotor symptoms and on neuroimmune RAGE network in experimental parkinsonism

This study newly shows that physical exercise (PE) corrects nonmotor symptoms of the intranasal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of experimental parkinsonism. Additionally, we show that suppression of neuroimmune receptor for advanced glycation end products (RAGE) network occurs in frontal cortex on chemical (MPTP) and physical (PE) interventions. Finally, PE normalizes frontal cortical RAGE transcriptomics and upregulates the neuroprotective DJ-1 gene in the intranasal MPTP model of experimental parkinsonism.

Source: Journal of Applied Physiology - July 18, 2017 Category: Physiology Authors: Viana, S. D., Pita, I. R., Lemos, C., Rial, D., Couceiro, P., Rodrigues-Santos, P., Caramelo, F., Carvalho, F., Ali, S. F., Prediger, R. D., Fontes Ribeiro, C. A., Pereira, F. C. Tags: RESEARCH ARTICLE Source Type: research