Individualized Assessment of Fracture Risk: Contribution of “Osteogenomic Profile”

Over the past decade, several genetic variants or genes for osteoporosis have been identified through genome-wide association studies and candidate gene association studies. These genetic variants are common in the general population but have modest effect sizes, with odds ratio ranging from 1.1 to 1.5. Thus, the utility of any single variant is limited. However, theoretical and empirical studies have suggested that a profiling of multiple variants that are associated with bone phenotypes (i.e., “osteogenomic profile”) can improve the accuracy of fracture prediction and classification beyond that obtained by conventional clinical risk factors.

Source: Journal of Clinical Densitometry - July 17, 2017 Category: Radiology Authors: Tuan V. Nguyen Tags: Original Article Source Type: research