Small Prosthetic Groups in 18F-Radiochemistry: Useful Auxiliaries for the Design of 18F-PET Tracers

Prosthetic group (PG) applications in 18F-radiochemistry play a pivotal role among current 18F-labeling techniques for the development and availability of 18F-labeled imaging probes for PET (Wahl, 2002) (1). The introduction and popularization of PGs in the mid-80s by pioneers in 18F-radiochemistry has profoundly changed the landscape of available tracers for PET and has led to a multitude of new imaging agents based on simple and efficiently synthesized PGs. Because of the chemical nature of anionic 18F − (apart from electrophilic low specific activity 18F-fluorine), radiochemistry before the introduction of PGs was limited to simple nucleophilic substitutions of leaving group containing precursor molecules.

Source: Seminars in Nuclear Medicine - July 17, 2017 Category: Nuclear Medicine Authors: Ralf Schirrmacher, Bj örn Wängler, Justin Bailey, Vadim Bernard-Gauthier, Esther Schirrmacher, Carmen Wängler Source Type: research