Identification of a novel HLA ‐B allele, HLA‐B*40:238, in a Taiwanese individual

Summary The HLA‐B*40:238 allele has one non‐synonymous transversion from HLA‐B*40:01:01 at nucleotide position 484. The HLA‐B*40:238 allele was found in an association study between HLA and antithyroid drug‐induced agranulocytosis 1. The allele, initially genotyped in a Graves' disease patient showed one mismatched nucleotide within the combined sequence pattern of B*40:01:01 and B*13:01:01 using SeCore HLA Sequence‐based typing kit (Life Technologies Corporation, WI, USA). To determine which allele the mismatch belonged to, polymerase chain reaction (PCR) was carried out to amplify exon 2 to exon 4 of the HLA‐B region with dimorphic forward primers as described by Cereb et al 2.
Source: Tissue Antigens - Category: Allergy & Immunology Authors: Tags: NEW ALLELE ALERTS Source Type: research