Escapees from Rhombomeric Lineage Restriction: Extensive Migration Rostral to the r4/r5 Border of Hox ‐a3 Expression

In this study we used Hoxa3‐Cre lineage to permanently mark cells that originate in rhombomeres caudal to r4. We found that cells born caudal to the r4/r5 border migrate forwards to a number of different locations in rhombomeres 1–4; the final locations include the interfascicular trigeminal nucleus, the principal trigeminal nucleus, the pontine nuclei, the reticulotegmental nucleus, the ventral nucleus of the lateral lemniscus, and the lateral and medial vestibular nuclei. We suggest that there are numerous exceptions to the principle of rhombomeric lineage restriction that have previously gone unnoticed. Anat Rec, 2017. © 2017 Wiley Periodicals, Inc.

Source: The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology - July 17, 2017 Category: Molecular Biology Authors: Charles Watson, Gayeshika Leanage, Nadja Makki, Petr Tvrdik Tags: Full Length Article Source Type: research