Cancer recurrence monitoring using hyperpolarized [1-13C]pyruvate metabolic imaging in murine breast cancer model
The purpose of this work was to study the anatomic and metabolic changes that occur with tumor progression, regression and recurrence in a switchable MYC-driven murine breast cancer model. Serial 1H MRI and hyperpolarized [1-13C]pyruvate metabolic imaging were used to investigate the changes in tumor volume and glycolytic metabolism over time during the multistage tumorigenesis. We show that acute de-induction of MYC expression in established tumors results in rapid tumor regression and significantly reduced glycolytic metabolism as measured by pyruvate-to-lactate conversion.
Source: Magnetic Resonance Imaging - Category: Radiology Authors: Peter J. Shin, Zihan Zhu, Roman Camarda, Robert A. Bok, Alicia Y. Zhou, John Kurhanewicz, Andrei Goga, Daniel B. Vigneron Tags: Original contribution Source Type: research