Analysis of TRALI and possible TRALI reported to the French Hemovigilance Network from 2007 to 2013

Using the French Hemovigilance Network database from 2007 to 2013, we provide information on demographics, incidence, and risk factors of reported TRALI and possible TRALI; analyse TRALI mitigation efforts for fresh frozen plasma and platelet concentrates; and consider the impact of platelet additive solutions on TRALI incidence. We applied the Toronto consensus conference definitions for TRALI and possible TRALI. Two TRALI subgroups were considered: “Antibody positive” when a donor has HLA (class I or II) and/or HNA antibodies and the recipient has cognate antigen, and “Antibody negative” when immunological investigation is negative or not done.

Source: Transfusion Medicine Reviews - July 14, 2017 Category: Hematology Authors: Georges Andreu, Karim Boudjedir, Jean-Yves Muller, Elodie Pouchol, Yves Ozier, Guillaume Fevre, Chantal Gautreau, Jean-Fran çois Quaranta, Christian Drouet, Claire Rieux, Paul-Michel Mertes, Benoit Clavier, Monique Carlier, Imad Sandid Source Type: research