Cl- channel is required for CXCL10-induced neuronal activation and itch response in a murine model of allergic contact dermatitis

This study revealed that CXCL10 evoked an ionic current mainly carried by Cl– channels. We suggest that Cl– channels are likely key molecular candidates responsible for the CXCL10-evoked neuronal activation and itch-like behaviors in a murine model of allergic contact dermatitis induced by the antigen squaric acid dibutylester. Cl– channels may emerge as a promising drug target for the treatment of allergic itch in which CXCL10/CXCR3 signaling may participate.
Source: Journal of Neurophysiology - Category: Neurology Authors: Tags: Research Articles Source Type: research