The Characteristics of Blood Supply and Tissue Hypoxia in Pathological Scars

Publication date: June 2017 Source:Chinese Medical Sciences Journal, Volume 32, Issue 2 Author(s): Zifei Li, Qingliang Liu, Xiaojun Wang, Jie Luan Blood supply is believed to be an important aspect in the development of pathological scars. However, there are controversies about vascular distribution, vascular structure and blood flow in pathological scars. Additionally, hypoxic microenvironment plays an important role in the vascularization of pathological scar tissues, and hypoxic conditions can be reflected by metabolic indexes and some cytokines. Furthermore, the correlation between blood supply and tissue hypoxia is controversial. The aim of this article is to review the literature on the characteristics of blood supply and tissue hypoxia in pathological scars, from which we can see pathological scars have unique characteristics of blood supply that are closely associated with tissue hypoxia. Moreover, development in the treatment of pathological scars is herein reviewed.
Source: Chinese Medical Sciences Journal - Category: General Medicine Source Type: research