Transendothelial movement of adiponectin is restricted by glucocorticoids

In conclusion, our study identifies glucocorticoid-mediated reductions in flux of Ad across endothelial monolayers in vivo and in vitro. This suggests that impaired Ad action in target tissues, as a consequence of reduced transendothelial flux, may contribute to the glucocorticoid-induced diabetic phenotype.

Source: Journal of Endocrinology - July 13, 2017 Category: Endocrinology Authors: Dang, T. Q., Yoon, N., Chasiotis, H., Dunford, E. C., Feng, Q., He, P., Riddell, M. C., Kelly, S. P., Sweeney, G. Tags: Research Source Type: research