Loss of histone H4K20 trimethylation predicts poor prognosis in breast cancer and is associated with invasive activity

Conclusions: H4K20me3 was reduced in cancerous regions of breast-tumor tissue, as in other types of tumor. Reduced H4K20me3 level can be used as an independent marker of poor prognosis in breast cancer patients. Most importantly, this study suggests that a reduced level of H4K20me3 increases the invasiveness of breast cancer cells in a HER2-independent manner.

http://breast-cancer-research.com/content/16/3/R66

Source: Breast Cancer Research - June 22, 2014 Category: Cancer & Oncology Authors: Yuhki YokoyamaAyaka MatsumotoMiki HiedaYoshimi ShinchiEri OgiharaMai HamadaYu NishiokaHiroshi KimuraKatsuhide YoshidomeMasahiko TsujimotoNariaki Matsuura Source Type: research