A review of bioregulatory and coupled mechanobioregulatory mathematical models for secondary fracture healing

Bone is a unique tissue that can renew itself and maintain skeletal integrity through resorption [1]. Unlike other tissues, bone tissue is a unique and the only tissue that can heal without scaring [2]. Despite bone ’s unique self-regeneration capacity and continuing research efforts, delayed healing and non-unions resulting from bone fractures often occur. Fractures not only bring pains to patients, but also cost societies large amounts of money. It is reported that the cost of treating non-unions is between £7 000 and £79 000 per person [3–6].
Source: Medical Engineering and Physics - Category: Biomedical Engineering Authors: Source Type: research