Prostate Cancer Risk and DNA Methylation Signatures in Aging Rats following Developmental BPA Exposure: A Dose –Response Analysis

Conclusions:
Developmental BPA exposures heighten prostate cancer susceptibility in a complex dose- and lobe-specific manner. Importantly, elevated carcinogenic risk is found at doses that yield undetectable serum free BPA. Dose-specific epigenetic modifications of selected genes provide a mechanistic framework that may connect early-life BPA to later-life predisposition to prostate carcinogenesis. https://doi.org/10.1289/EHP1050

Received: 1 September 2016
Revised: 13 January 2017
Accepted: 19 January 2017
Published: 11 July 2017
Address correspondence to G.S. Prins, Dept. of Urology, University of Illinois at Chicago, 820 South Wood St., M/C 955, Chicago, IL 60612 USA. Telephone: [phone]. Email: [e-mail]
Supplemental Material is available online (https://doi.org/10.1289/EHP1050).
The authors declare they have no actual or potential competing interests.
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Source: EHP Research - July 11, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research