[Correspondence] Lessons from the Multidomain Alzheimer Preventive Trial

The Multidomain Alzheimer Preventive Trial (MAPT) investigators should be commended for their work on one of the larger and longer duration multicentre trials to investigate dementia prevention.1 The results of MAPT showed no significant effects with any of the three treatment interventions compared with placebo on the primary outcomes, the 15 secondary outcomes (except for one comparison of combined intervention with placebo on the ten item Mini-Mental State Examination, p=0 ·036), or on five of seven prespecified and exploratory subgroup analyses, which compared a multidomain intervention combined with omega 3 polyunsaturated fatty acids or placebo, or omega 3 capsules alone, against placebo capsules in old adults with memory complaints.

Source: Lancet Neurology - July 12, 2017 Category: Neurology Authors: Hussein N Yassine, Lon S Schneider Tags: Correspondence Source Type: research