Cell type-specific changes in retinal ganglion cell function induced by rod death and cone reorganization in rats

This study provides novel and therapeutically relevant insights to retinal function following rod death but before cone death. To determine changes in retinal output, we used a large-scale multielectrode array to simultaneously record from hundreds of retinal ganglion cells (RGCs). These recordings of large-scale neural activity revealed that following the death of all rods, functionally distinct RGCs remain. However, the receptive field properties and spontaneous activity of these RGCs are altered in a cell type-specific manner.
Source: Journal of Neurophysiology - Category: Neurology Authors: Tags: Research Articles Source Type: research