Elimination of large tumors in mice by mRNA-encoded bispecific antibodies

Nature Medicine 23, 815 (2017).
doi:10.1038/nm.4356

Authors: Christiane R Stadler, Hayat Bähr-Mahmud, Leyla Celik, Bernhard Hebich, Alexandra S Roth, René P Roth, Katalin Karikó, Özlem Türeci & Ugur Sahin
The potential of bispecific T cell–engaging antibodies is hindered by manufacturing challenges and short serum half-life. We circumvented these limitations by treating mice with in vitro–transcribed pharmacologically optimized, nucleoside-modified mRNA encoding the antibody. We achieved sustained endogenous synthesis of the antibody, which eliminated advanced tumors as effectively as the corresponding purified bispecific antibody. Because manufacturing of pharmaceutical mRNA is fast, this approach could accelerate the clinical development of novel bispecific antibodies.

Source: Nature Medicine - June 12, 2017 Category: General Medicine Authors: Christiane R Stadler Hayat B ä hr-Mahmud Leyla Celik Bernhard Hebich Alexandra S Roth Ren é P Roth Katalin Karik ó Ö zlem T ü reci Ugur Sahin Tags: Brief Communication Source Type: research