Proficient synthesis of bioactive annulated pyrimidine Derivatives: A review

Publication date: Available online 10 July 2017 Source:Journal of Taibah University for Science Author(s): Ajmal R. Bhat, Rajendra S. Dongre, Gowhar A. Naikoo, Israr U. Hassan, Tabassum Ara Synthesis of bioactive annulated pyrimidine derivativies are the most significant tasks in N-heterocyclic chemistry, as proved to be very attractive and constructive for the design of a new molecular framework of potential drugs with varying pharmacological activities. This review paper summarizes the one-pot multicomponent synthesis of annulated Nitrogen and oxygen-containing heterocycles, such as Pyrano[2,3-d]pyrimidines, Pyrido[2,3-d]pyrimidines and Pyrido[2,3-d;5-6-d]dipyrimidines. The synthetic procedure is based on the chemistry of domino Knoevenagel-Michael addition mechanism.

Source: Journal of Taibah University for Science - July 11, 2017 Category: Science Source Type: research